(R)-4-((R)-1-((6-chloro-3-methyl-3H-imidazo[4,5-c]pyridin-4-yl)oxy)ethyl)pyrrolidin-2-one → 1,4-Dihydro-2H-3,1-benzoxazin-2-one

HRID 2209096

Reaktionsgleichung

Reaktionsgleichung von HRID 2209096
ClC1N=C(O[C@@H]([C@H]2CNC(=O)C2)C)C2N(C)C=NC=2C=1.C[N:22]1[C:27]2[CH:28]=[C:29](B3OC(C)(C)C(C)(C)O3)[CH:30]=[CH:31][C:26]=2[C:25](C)(C)[O:24][C:23]1=[O:43]>>[NH:22]1[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=2[CH2:25][O:24][C:23]1=[O:43]

Komponenten

3

Edukt 2

HCID 117843294(R)-4-((R)-1-((6-chloro-3-methyl-3H-imidazo[4,5-c]pyridin-4-yl)oxy)ethyl)pyrrolidin-2-oneHCID 1234331871,4,4-Trimethyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,1-benzoxazin-2-one

Produkt 1

HCID 257861,4-Dihydro-2H-3,1-benzoxazin-2-one

Versuchsvorschrift

Following general procedure A, starting from (R)-4-((R)-1-((6-chloro-3-methyl-3H-imidazo[4,5-c]pyridin-4-yl)oxy)ethyl)pyrrolidin-2-one: (63 mg), and 1,4,4-trimethyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d][1,3]oxazin-2(4H)-one (67 mg), 55 mg of 1,4,4-trimethyl-7-(3-methyl-4-4R)-1-((R)-5-oxopyrrolidin-3-yl)ethoxy)-3H-imidazo[4,5-c]pyridin-6-yl)-1H-benzo[d][1,3]oxazin-2(4H)-one was synthesized.

Quellen und Nachweise

ORD-Eintrag
ord-797c578854834f7997054ea43fcb10e5
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09376441B2

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