HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 221Erstellt: 27. Oktober 2026
Iodobenzene → tert-butyl N-[2-(1-phenylpiperidin-4-yl)ethyl]carbamate
https://huagongshe.com/reaction/221
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Iodobenzene | HCID 11575 | — |
| Edukt | 4-(2-Aminoethyl)piperidine, 4-BOC protected | HCID 1501849 | — |
| Reagenz | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Katalysator | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| Katalysator | Bis(tri-tert-butylphosphine)palladium(0) | HCID 2734558 | — |
| Lösungsmittel | 1,2-Dimethoxyethane | HCID 8071 | — |
| Produkt | tert-butyl N-[2-(1-phenylpiperidin-4-yl)ethyl]carbamate | HCID 69152784 | 0% |
Reaktionsschritte
To a solution of tert-butyl 2-(piperidin-4-yl)ethylcarbamate (0.342 g, 1.5 mmol) in anhydrous DME were added iodobenzene (0.444 g, 2.18 mmol), bis(tri-t- butylphosphine)palladium(0) (0.077 g, 0.15 mmol) and potassium phosphate (0.245 mL, 3.00 mmol). The reaction was heated to 100°C overnight. This reaction did not work.
Herkunft & Nachweise
| Quelldatensatz | 750 AstraZeneca ELN dataset |
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| ORD ID | ord-cc832050b1854993a53bbd02bde64312 |
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| Quellennotiz | 750 AstraZeneca ELN dataset |
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