Methylamine → 2-(Methylamino)pyridine-3-sulfonamide
Reaktionsgleichung
Cl[C:2]1[C:7]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][NH2:13]>>[CH3:12][NH:13][C:2]1[C:7]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1Komponenten
3
Versuchsvorschrift
10 g of 2-chloropyridine-3-sulfonamide (obtained in Stage A of Preparation 6) are dissolved in 100 cm3 of 40% aqueous methylamine solution and the solution is introduced into a sealed tube. The tube is placed at 150° C. for 18 hours. After cooling, the reaction mixture is concentrated under vacuum (rotary evaporator) to a volume of 30 cm3. The crystalline precipitate corresponding to the title compound is collected on a filter, washed with water and dried.
Aufarbeitung
- additionthe solution is introduced into a sealed tube
- temperatureAfter cooling
- concentrationthe reaction mixture is concentrated under vacuum (rotary evaporator) to a volume of 30 cm3
- customThe crystalline precipitate corresponding to the title compound is collected on a filter
- washwashed with water
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-f20e352cd68a42d2919010920f79ffe3
- Quelldatensatz
- uspto-grants-1995_10
- Patentnummer
- US05459138
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