2-(Trifluoromethyl)thiophene → 5-Bromo-2-chloro-1-(5-trifluoromethyl-2-thienylmethyl)benzene

Reaktionsgleichung

[F:1][C:2]([F:9])([F:8])[C:3]1[S:4][CH:5]=[CH:6][CH:7]=1.[Br:10][C:11]1[CH:12]=[CH:13][C:14]([Cl:19])=[C:15]([CH:18]=1)[CH:16]=O>>[Br:10][C:11]1[CH:12]=[CH:13][C:14]([Cl:19])=[C:15]([CH2:16][C:5]2[S:4][C:3]([C:2]([F:9])([F:8])[F:1])=[CH:7][CH:6]=2)[CH:18]=1

Komponenten

Edukt 2

HCID 27607852-(Trifluoromethyl)thiophene

HCID 106089255-Bromo-2-chlorobenzaldehyde

Produkt 1

HCID 666086355-Bromo-2-chloro-1-(5-trifluoromethyl-2-thienylmethyl)benzene

Versuchsvorschrift

2-Trifluoromethylthiophene (see Japanese Unexamined Patent Publication No. 2000-34239) and 5-bromo-2-chlorobenzaldehyde obtained in Reference Example 16-(1) were treated in a manner similar to Reference Example 7 to give the target compound.

Aufarbeitung

additionwere treated in a manner similar to Reference Example 7
customto give the target compound

Quellen und Nachweise

ORD-Eintrag: ord-674e48087f914642acaffb0392ce1fad
Quelldatensatz: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08202984B2

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