[O:1]1[CH:5]=[CH:4][C:3]([NH:6][C:7]2[C:8]([N+:17]([O-])=O)=[C:9]3[CH2:16][O:15][CH2:14][CH2:13][C:10]3=[N:11][CH:12]=2)=[N:2]1.ClC(Cl)(Cl)C(NC1C=[N+]([O-])C2CCCCC=2C=1)=O>CO.[C].[Pd]>[NH2:17][C:8]1[C:7]([NH:6][C:3]2[CH:4]=[CH:5][O:1][N:2]=2)=[CH:12][N:11]=[C:10]2[CH2:13][CH2:14][O:15][CH2:16][C:9]=12To a solution of 435 mg of Compound 7 obtained in (3) above in 95% aqueous methanol is added 10% palladium carbon (40 mg) as catalyst, and the resultant mixture is hydrogenated at ordinary temperature under atmospheric pressure. The reaction mixture is filtered, and the hardly soluble solid is washed out with dimethylformamide. The filtrate is concentrated in vacuo, and the residue is recrystallized from methanol-methylene chloride to give 280 mg of the titled compound (II2b) as light brown crystals. Yield: 72% mp.: 209° to 211° C. Elemental Analysis (%) C12H12N4O3Calculated: C, 55.38; H, 4.65; N, 21.53 Found: C, 55.08; H, 4.54; N, 21.24 NMR (d6 -DMSO) δ: 2.73 (2H, t); 3.90 (2H, t); 4.51 (2H, s); 5.93 (2H, s, NH); 7.06 (1H, d); 7.93 (1H, s); 9.15 (1H, d); 10.07 (1H, s, NH)
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