Thionyl Chloride → 5-(Chloromethyl)uracil

HRID 2211817

Reaktionsgleichung

Reaktionsgleichung von HRID 2211817
S(Cl)([Cl:3])=O.O[CH2:6][C:7]1[C:8](=[O:14])[NH:9][C:10](=[O:13])[NH:11][CH:12]=1>O1CCOCC1>[Cl:3][CH2:6][C:7]1[C:8](=[O:14])[NH:9][C:10](=[O:13])[NH:11][CH:12]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 781685-(Hydroxymethyl)uracil

Produkt 1

HCID 2361255-(Chloromethyl)uracilAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Thionyl chloride ((10 ml) was added to a suspension of 5-(hydroxymethyl)-2,4(1H,3H)-pyrimidinedione (0.60 g, 4.2 mmol)from step (11a) in dioxane (15 ml). The reaction was heated to reflux for 4 h, allowed to cool, and concentrated in vacuo to give the 5-(chloromethyl)-2,4(1H,3H)-pyrimidinedione (0.62 g, 100%) as a yellow solid.

Aufarbeitung

  1. temperatureThe reaction was heated
  2. temperatureto reflux for 4 h
  3. temperatureto cool
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7ba52a75ba89449ebaa88639d2057de4
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07101883B2

Verknüpfte Notizen

Wird geladen…