Hexyl chloroformate → HCID 178445090, Verbindung

HRID 2212114

Reaktionsgleichung

Reaktionsgleichung von HRID 2212114
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13](=[O:14])[C:12](=[O:15])[N:11]=[C:10]2[NH:16][C:17]([NH:19][CH:20]([CH3:22])[CH3:21])=[NH:18])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl[C:24]([O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[O:25]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13](=[O:14])[C:12](=[O:15])[NH:11][C:10]2=[N:16][C:17]([NH:19][CH:20]([CH3:22])[CH3:21])=[N:18][C:24]([O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[O:25])[CH:5]=[CH:6][C:7]=1[Cl:8]

Komponenten

3

Edukt 2

HCID 22466Hexyl chloroformateHCID 178457580HCID 178457580, Verbindung

Produkt 1

HCID 178445090HCID 178445090, Verbindung

Versuchsvorschrift

Compound 4e was prepared by the same method for preparation of 4b, using pure compound 4 (0.800 g, 2.34 mmol) and hexyl chloroformate as starting materials to yield compound 4e as a white color crystal (0.354 g, 32%). 1H NMR (300 MHz, CDCl3) δ 12.45 (s, 1H), 7.57–7.54 (m, 2H), 7.31–7.27 (dd, J=8.5 and 2.4 Hz, 1H), 4.25 (t, J=6.8 Hz, 2H), 4.12 (m, 1H),1.74 (m, 2H), 1.35 (m, 6H), 1.25 (d, J=6.6 Hz, 6H), 0.93 (t, J=6.4 Hz, 3H); 13C NMR: δ170.78, 168.50, 159.20, 155.93, 154.15, 132.56, 132.18, 131.50, 130.41, 128.62, 125.61, 31.31, 28.38, 25.32, 22.49, 22.30, 14.00. MS m/z 470 (M+), 418, 416, 368, 342, 314, 272, 230, 174.

Quellen und Nachweise

ORD-Eintrag
ord-c390b5c37a274c4abc301b2b61e3c8d1
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07101902B2

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