Pyridiniumtribromide → 3-Bromo-2,5-difluoro-4-hydroxybenzaldehyde

HRID 2212594

Reaktionsgleichung

Reaktionsgleichung von HRID 2212594
[F:1][C:2]1[CH:9]=[C:8]([OH:10])[C:7]([F:11])=[CH:6][C:3]=1[CH:4]=[O:5].[Br-:12].[Br-].[Br-].[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1>ClCCl>[Br:12][C:9]1[C:2]([F:1])=[C:3]([CH:6]=[C:7]([F:11])[C:8]=1[OH:10])[CH:4]=[O:5]

Komponenten

4

Edukt 2

HCID 21124087PyridiniumtribromideHCID 219664622,5-Difluoro-4-hydroxybenzaldehyde

Produkt 1

HCID 219664683-Bromo-2,5-difluoro-4-hydroxybenzaldehydeAusbeute 86.169,102 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

To a solution of 2,5-difluoro-4-hydroxybenzaldehyde (37.5 g, 0.237 mmol) in dichloromethane (1.5 L) was added pyridinium tribromide (75.9 g, 0.237 mmol). The reaction mixture was stirred at 40° C. for 7 hrs then at room temperature overnight. The reaction was washed with water and brine, dried over magnesium sulfate, filtered and evaporated to give 48.4 g of crude 3-bromo-2,5-difluoro-4-hydroxybenzaldehyde use as this in the next step.

Aufarbeitung

  1. customat room temperature
  2. customovernight
  3. washThe reaction was washed with water and brine
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-3b3a167c1c65433486f8a9691f5fee0a
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07102000B2

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