Dicyclohexylcarbodiimide → Benzoic acid, 3-amino-5-nitro-, ethyl ester

HRID 2212842Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2212842
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)[C:5]([OH:7])=[O:6].[CH2:14]1CCC(N=C=NC2CCCCC2)C[CH2:15]1>CCO>[CH2:14]([O:6][C:5](=[O:7])[C:4]1[CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=[C:2]([NH2:1])[CH:3]=1)[CH3:15]

Komponenten

4

Edukt 2

HCID 10868DicyclohexylcarbodiimideHCID 2393423-Amino-5-nitrobenzoic acid

Produkt 1

HCID 826201Benzoic acid, 3-amino-5-nitro-, ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

3-Amino-5-nitrobenzoic acid (910 mg, 5.0 mmol) was dissolved in EtOH (25 mL). DCC (1.51 g, 7.3 mmol) was added, and the mixture was stirred under reflux overnight. The solid precipitation was filtered off and the filtrate was evaporated. The residue was triturated in the solvent mixture ether:hexane:ethyl acetate, 5:5:1. The title compound was isolated as a fine light yellow powder (0.9 g, 85.7%).

Aufarbeitung

  1. temperatureunder reflux overnight
  2. customThe solid precipitation
  3. filtrationwas filtered off
  4. customthe filtrate was evaporated
  5. customThe residue was triturated in the solvent mixture ether

Quellen und Nachweise

ORD-Eintrag
ord-7e16ced096ee4eabba61e01d23bdef25
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07105503B2

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