HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Amino-6-chlorobenzoic acid → 2-[2-tert-butoxy-1-(9H-purin-6-ylamino)-ethyl]-3-phenyl-3H-quinazolin-4-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Amino-6-chlorobenzoic acid | HCID 75071 | — |
| Edukt | 6-Methylanthranilic acid | HCID 151210 | — |
| Edukt | Z-O-tert-butyl-L-serine N-hydroxysuccinimide ester | HCID 2729196 | — |
| Edukt | (2,5-Dioxopyrrolidin-1-yl) 2-(phenylmethoxycarbonylamino)butanoate | HCID 12961228 | — |
| Edukt | HCID 178456854 | HCID 178456854 | — |
| Produkt | 2-[2-tert-butoxy-1-(9H-purin-6-ylamino)-ethyl]-3-phenyl-3H-quinazolin-4-one | HCID 178450505 | — |
Reaktionsschritte
2-[2-tert-butoxy-1-(9H-purin-6-ylamino)-ethyl]-3-phenyl-3H-quinazolin-4-one was prepared using the general procedure described above with respect to compound 14, but 2-amino-6-chlorobenzoic acid was substituted for 2-amino-6-methylbenzoic acid in step A, 2-benzyloxycarbonylamino-3-tert-butoxy-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidin-1-yl ester in step B, and the conditions used in step C removed both the benzyl protecting group and the A-Ring chloro substituent.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08207153B2 |
| Quelldatensatz | uspto-grants-2012_06 |
| ORD ID | ord-323a7b7e7bd74b7289b501d3ed21f73b |
| Quellennotiz | uspto-grants-2012_06 |