Ammonia → 4-Carbamoylmethoxypiperidine-1-carboxylic acid tert-butyl ester

Temperatur

0 °C

A solution of 4-carboxymethoxypiperidine-1-carboxylic acid tert-butyl ester (Preparation 1, 14.13 g, 54.7 mmol) and triethylamine (7.68 ml, 65.6 mmol) in anhydrous THF (250 ml) was cooled to 0° C. and isobutylchloroformate (8.51 ml, 65.6 mmol) introduced dropwise. After stirring at 0° C. for 30 min, the reaction mixture was cooled to −20° C. and added rapidly via cannula to a solution of 0.7M ammonia in anhydrous CH2Cl2 (250 ml, 180 mmol) at −70° C. The reaction was allowed to warm to rt and stirred for 1 h. The mixture was diluted with CH2Cl2 (250 ml) and washed with saturated aqueous NaHCO3 (200 ml), 0.5M HCl (200 ml) and brine (200 ml) then dried (MgSO4). The solvent was evaporated and the residue purified by flash chromatography IH-THF 3:7) to afford the title compound: δH (CDCl3) 1.49 (9H, s), 1.53-1.60 (2H, m), 1.85-1.92 (2H, m), 3.11 (2H, m), 3.58 (1H, m), 3.76-3.83 (2H, m), 3.98 (2H, s), 6.19 (1H, bs), 6.56 (1H, bs).

1. temperaturethe reaction mixture was cooled to −20° C.
2. temperatureto warm to rt
3. stirringstirred for 1 h
4. washwashed with saturated aqueous NaHCO3 (200 ml), 0.5M HCl (200 ml) and brine (200 ml)
5. dry with materialthen dried (MgSO4)
6. customThe solvent was evaporated
7. customthe residue purified by flash chromatography IH-THF 3:7)

ORD-Eintrag

ord-90709735d32e4296963aec901ff714a8

Quelldatensatz

uspto-grants-2012_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08207147B2