Toluene → HCID 21957938, Verbindung

HRID 2213656Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2213656
[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][NH:14][C:15]2[CH:20]=[CH:19][C:18](C(C)C)=[CH:17][CH:16]=2)[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:24]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([CH:33]([CH3:35])[CH3:34])[C:28]=1[N:36]=[C:37]=[O:38])([CH3:26])[CH3:25].[C:39]1(C)[CH:44]=CC=C[CH:40]=1>>[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][N:14]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:20]=2[CH:39]([CH3:44])[CH3:40])[C:37]([NH:36][C:28]2[C:29]([CH:33]([CH3:34])[CH3:35])=[CH:30][CH:31]=[CH:32][C:27]=2[CH:24]([CH3:25])[CH3:26])=[O:38])[CH:10]=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 3

HCID 1140TolueneHCID 922592,6-Diisopropylphenyl isocyanateHCID 21957926HCID 21957926, Verbindung

Produkt 1

HCID 21957938HCID 21957938, Verbindung

Versuchsvorschrift

To a solution of [(1-benzylpyrazol-4-yl)methyl](4-isopropylphenyl)amine (0.17 g) in toluene (5 mL) was added 2,6-diisopropylphenyl isocyanate (0.12 mL) and the mixture was stirred overnight at room temperature. The reaction mixture was washed with saturated brine and dried over magnesium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography to give N-[(1-benzylpyrazol-4-yl)methyl]-N′-(2,6-diisopropylphenyl)-N-(isopropylphenyl)urea (0.24 g).

Aufarbeitung

  1. washThe reaction mixture was washed with saturated brine
  2. dry with materialdried over magnesium sulfate
  3. customThe solvent was evaporated under reduced pressure
  4. customthe residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-ef089b70f1ce4cba833edbf8a9a8f553
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07105567B2

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