4-amino-1-benzyl-3-nitro-1H-pyridin-2-one → 3,4-diamino-1-benzyl-1H-pyridin-2-one

HRID 2214449Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2214449
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:4](=[O:15])[C:3]=1[N+:16]([O-])=O>O1CCCC1.[Pt]=O>[CH2:8]([N:5]1[CH:6]=[CH:7][C:2]([NH2:1])=[C:3]([NH2:16])[C:4]1=[O:15])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Komponenten

4

Edukt 1

HCID 219476414-amino-1-benzyl-3-nitro-1H-pyridin-2-one

Produkt 1

HCID 219476293,4-diamino-1-benzyl-1H-pyridin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

3.9 g (15.9 mmol) of 4-amino-1-benzyl-3-nitro-pyridin-2-one, dissolved in 250 ml of tetrahydrofuran, were hydrogenated over platinum oxide at 50 psi of H2 pressure and at ambient temperature. After the catalyst had been filtered off the filtrate was concentrated by evaporation and the residue was further processed in crude form.

Aufarbeitung

  1. filtrationAfter the catalyst had been filtered off the filtrate
  2. concentrationwas concentrated by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-f674d1a0772a4efb9347181944e7969b
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07109192B2

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