Potassium Carbonate → cis-6-(3,5-Dimethylpiperazin-1-yl)-5-methoxyindoline

HRID 2214753Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2214753
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([O:21][CH3:22])=[C:10]([N:13]3[CH2:18][C@H:17]([CH3:19])[NH:16][C@H:15]([CH3:20])[CH2:14]3)[CH:11]=2)[CH2:6][CH2:5]1)(=O)C.C([O-])([O-])=O.[K+].[K+]>Cl>[CH3:20][C@H:15]1[NH:16][C@@H:17]([CH3:19])[CH2:18][N:13]([C:10]2[CH:11]=[C:12]3[C:7]([CH2:6][CH2:5][NH:4]3)=[CH:8][C:9]=2[O:21][CH3:22])[CH2:14]1

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 69664906cis-1-Acetyl-6-(3,5-dimethylpiperazin-1-yl)-5-methoxyindoline

Produkt 1

HCID 11265480cis-6-(3,5-Dimethylpiperazin-1-yl)-5-methoxyindolineAusbeute 107,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

A stirred solution of D2 (1.6 g, 5 mmole) in 2M HCl acid (50 ml) was heated under reflux for 2 h, then allowed to cool, basified with K2CO3 and extracted with DCM. The extract was dried (Na2SO4) and concentrated under vacuum to afford the title compound as a pale orange solid (1.4 g, 100%). MH+ 276.

Aufarbeitung

  1. temperatureunder reflux for 2 h
  2. temperatureto cool
  3. extractionextracted with DCM
  4. dry with materialThe extract was dried (Na2SO4)
  5. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-7ddca317ee804d899f4ca913d4e9e9ca
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07109201B2

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