HCID 21948929, Verbindung → HCID 21948915, Verbindung

HRID 2215437Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2215437
[C:1]([O:4][CH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[N+:16]([O-])=O)[N:7]=1)(=[O:3])[CH3:2]>CC(C)=O.[Ni]>[C:1]([O:4][CH2:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[NH2:16])[N:7]=1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 21948929HCID 21948929, Verbindung

Produkt 1

HCID 21948915HCID 21948915, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 180AcetoneLösungsmittel2×

Versuchsvorschrift

Under hydrogen atmosphere, a solution that consists of 410 mg (1.67 mol) of 2-(acetoxymethyl)-5-nitroquinoline in 61 ml of acetone can be stirred in the presence of 410 mg of Raney nickel for 2 hours at room temperature. It is suctioned off on Celite and rewashed with acetone. After removal of the solvent and subsequent chromatography on silica gel with hexane-ethyl acetate (10–100%), 230 mg (64% of theory) of the product is obtained.

Aufarbeitung

  1. customAfter removal of the solvent and subsequent chromatography on silica gel with hexane-ethyl acetate (10–100%), 230 mg (64% of theory) of the product
  2. customis obtained

Quellen und Nachweise

ORD-Eintrag
ord-12a722f59f714dc5bbcc989cc01640d2
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07109212B2

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