3-Ethylpent-1-yn-3-amine → 3-[2-Benzyl-6-[(3R,4R)-3-hydroxy-4-methoxypyrrolidin-1-yl]-3-pyridyl]-1,1-diethyl-2-propynylamine

HRID 2216379

Reaktionsgleichung

Reaktionsgleichung von HRID 2216379
[CH2:1]([C:8]1[C:13](I)=[CH:12][CH:11]=[C:10]([N:15]2[CH2:19][C@@H:18]([O:20][CH3:21])[C@H:17]([OH:22])[CH2:16]2)[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:23]([C:25]([NH2:30])([CH2:28][CH3:29])[C:26]#[CH:27])[CH3:24]>>[CH2:1]([C:8]1[C:13]([C:24]#[C:23][C:25]([NH2:30])([CH2:28][CH3:29])[CH2:26][CH3:27])=[CH:12][CH:11]=[C:10]([N:15]2[CH2:19][C@@H:18]([O:20][CH3:21])[C@H:17]([OH:22])[CH2:16]2)[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 767103-Ethylpent-1-yn-3-amineHCID 113843072-Benzyl-3-iodo-6-[(3R,4R)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridine

Produkt 1

HCID 101786983-[2-Benzyl-6-[(3R,4R)-3-hydroxy-4-methoxypyrrolidin-1-yl]-3-pyridyl]-1,1-diethyl-2-propynylamine

Versuchsvorschrift

This was synthesized in the same manner as in Example 6 except that 2-benzyl-3-iodo-6-[(3R,4R)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridine (Production Example 1) and 1,1-diethyl-2-propynylamine were used.

Quellen und Nachweise

ORD-Eintrag
ord-50d9ab31ff72496c80961e78f6887487
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07112593B2

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