Ammonium Chloride → 5-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride

HRID 2216567Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2216567
CO[C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1.[Cl-:11].[NH4+:12]>C(O)C>[ClH:11].[NH2:12][C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1

Komponenten

4

Edukt 2

HCID 25517Ammonium ChlorideHCID 219414705-methoxy-1-methyl-3,6-dihydro-1H-pyrazin-2-one

Produkt 1

HCID 219413655-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 5-methoxy-1-methyl-3,6-dihydro-1H-pyrazin-2-one (2.3 g) and ammonium chloride (936 mg) in dry ethanol (32 mL) was stirred at room temperature for 1 h and then refluxed for 2 h. The reaction mixture was cooled to room temperature and evaporated under reduced pressure. The residue was triturated with chloroform at room temperature for 30 min. The precipitate was filtered off and dried in vacuo. The 5-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride was obtained as a pale brown powder (1.7 g, 66%).

Aufarbeitung

  1. temperaturerefluxed for 2 h
  2. temperatureThe reaction mixture was cooled to room temperature
  3. customevaporated under reduced pressure
  4. customThe residue was triturated with chloroform at room temperature for 30 min
  5. filtrationThe precipitate was filtered off
  6. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b0fe5107481641fdb832ad186f8ed23a
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07112582B2

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