Iodine → HCID 49796119, Verbindung

HRID 2217324Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2217324
[C:1]1(=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[NH2:11][C:12]([NH2:14])=[S:13].[I:15]I>>[IH:15].[S:13]1[C:2]2[CH2:3][C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=3[C:1]=2[N:11]=[C:12]1[NH2:14]

Komponenten

4

Edukt 3

HCID 807IodineHCID 67351-IndanoneHCID 2723790Thiourea

Produkt 1

HCID 49796119HCID 49796119, VerbindungAusbeute 63,6 %

Reaktionsbedingungen

Temperatur
95 °C

Versuchsvorschrift

A mixture of 1-indanone (6.00 g; 45.4 mmol), thiourea (6.92 g; 90.8 mmol) and iodine (11.52 g; 45.4 mmol) was heated to 95° C. with stirring. After 3 hours, the mixture was allowed to cool to room temperature. The crude solid was triturated with absolute ethanol and filtered. The light yellow solid was washed twice with absolute ethanol then allowed to air dry to provide 9.13 g of 8H-Indeno[1,2-d]thiazol-2-ylamine hydroiodide 1a.

Aufarbeitung

  1. temperatureto cool to room temperature
  2. customThe crude solid was triturated with absolute ethanol
  3. filtrationfiltered
  4. washThe light yellow solid was washed twice with absolute ethanol
  5. customto air dry

Quellen und Nachweise

ORD-Eintrag
ord-ac00b36fa8e340249cdc3ae5fd4976e4
Quelldatensatz
uspto-grants-2008_08
Patentnummer
US07407977B2

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