Cyclopentanepropanoic acid → N-5-Quinolinyl-cyclopentanepropanamide

HRID 2217814

Reaktionsgleichung

Reaktionsgleichung von HRID 2217814
[N:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([NH2:11])[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH:12]1([CH2:17][CH2:18][C:19](O)=[O:20])[CH2:16][CH2:15][CH2:14][CH2:13]1>>[N:1]1[C:10]2[C:5](=[C:6]([NH:11][C:19](=[O:20])[CH2:18][CH2:17][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Komponenten

3

Edukt 2

HCID 8818Cyclopentanepropanoic acidHCID 119115-Aminoquinoline

Produkt 1

HCID 2107517N-5-Quinolinyl-cyclopentanepropanamideAusbeute 24,1 %

Versuchsvorschrift

Prepared according to the method of example 18, using 5-quinolinamine (250 mg) and cyclopentanepropanoic acid (270 mg). Purification (HPLC, Symmetry—0.1% aqueous trifluoroacetic acid/acetonitrile) followed by recrystallisation from methanol/ethyl acetate gave the title compound as a colourless solid (112 mg).

Aufarbeitung

  1. customPrepared
  2. customPurification (HPLC, Symmetry—0.1% aqueous trifluoroacetic acid/acetonitrile)
  3. customfollowed by recrystallisation from methanol/ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-a80433abb70a48ee91e47047b46d9861
Quelldatensatz
uspto-grants-2008_08
Patentnummer
US07408065B2

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