2,6-Dichloroquinolin-5-amine → 1-Cyclohexyl-N-(2,6-dichloro-5-quinolinyl)-cyclopropanecarboxamide

HRID 2217820Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2217820
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:8]([NH2:12])=[C:7]([Cl:13])[CH:6]=[CH:5][C:4]=2[N:3]=1.[CH:14]1([C:20]2([C:23](O)=[O:24])[CH2:22][CH2:21]2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[CH:14]1([C:20]2([C:23]([NH:12][C:8]3[C:7]([Cl:13])=[CH:6][CH:5]=[C:4]4[C:9]=3[CH:10]=[CH:11][C:2]([Cl:1])=[N:3]4)=[O:24])[CH2:21][CH2:22]2)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1

Komponenten

3

Edukt 2

HCID 248203742,6-Dichloroquinolin-5-amineHCID 537450231-Cyclohexylcyclopropane-1-carboxylic acid

Produkt 1

HCID 860130111-Cyclohexyl-N-(2,6-dichloro-5-quinolinyl)-cyclopropanecarboxamideAusbeute 50,8 %

Versuchsvorschrift

Prepared according to the method of example 1(a), using 2,6-dichloro-5-quinolinamine (prepared as described in Example 1(d)) (0.3 g) and 1-cyclohexyl cyclopropanecarboxylic acid (Example 26(a)) (0.28 g) at 100° C. for 15 hours. Purification by chromatography (SiO2, dichloromethane as eluant) afforded the sub-title compound (0.26 g).

Aufarbeitung

  1. customPrepared
  2. customat 100° C.
  3. customfor 15 hours
  4. customPurification by chromatography (SiO2, dichloromethane as eluant)

Quellen und Nachweise

ORD-Eintrag
ord-aaf481ec2c2b46d1b699aee8cfedb2d3
Quelldatensatz
uspto-grants-2008_08
Patentnummer
US07408065B2

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