Methylamine → N-[6-Chloro-2-[(3R)-3-(methylamino)-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide

HRID 2217829Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2217829
[Cl:1][C:2]1[C:3]([NH:22][C:23](=[O:31])[CH2:24][CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:12]1[CH2:16][CH2:15][C@H:14](OS(C)(=O)=O)[CH2:13]1)[CH:6]=[CH:5]2.[CH3:32][NH2:33]>C(O)C>[Cl:1][C:2]1[C:3]([NH:22][C:23](=[O:31])[CH2:24][CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:12]1[CH2:16][CH2:15][C@@H:14]([NH:33][CH3:32])[CH2:13]1)[CH:6]=[CH:5]2

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 86609739N-[6-Chloro-2-[(3S)-3-[(methylsulfonyl)oxy]-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide

Produkt 1

HCID 11269597N-[6-Chloro-2-[(3R)-3-(methylamino)-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a 10 mL vial was added N-[6-Chloro-2-[(3S)-3-[(methylsulfonyl)oxy]-1-pyrrolidinyl]-5-quinolinyl]-cyclohexaneacetamide (Example 33(a)) (225 mg) and 8M methylamine in ethanol (6 mL). The vial was sealed and heated at 80° C. for 120 minutes within a microwave. The solvent was removed under vacuum and purified (SiO2, ammonia:methanol:dichloromethane, 1:2:97 as eluant) to afford the titled compound (0.033 g).

Aufarbeitung

  1. customThe vial was sealed
  2. customThe solvent was removed under vacuum
  3. custompurified (SiO2, ammonia:methanol:dichloromethane, 1:2:97 as eluant)

Quellen und Nachweise

ORD-Eintrag
ord-4f1e934f0d944a38b5eb091b9701b196
Quelldatensatz
uspto-grants-2008_08
Patentnummer
US07408065B2

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