Hydrochloric Acid → 8-Cyclopropyl-4-ethoxyquinoline-2-carboxylic acid

HRID 2218308Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2218308
[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[C:9]([CH:14]3[CH2:16][CH2:15]3)[CH:10]=[CH:11][CH:12]=2)[N:7]=[C:6]([C:17]([O:19]C)=[O:18])[CH:5]=1)[CH3:2].Cl>C(Cl)(Cl)Cl.CO>[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[C:9]([CH:14]3[CH2:16][CH2:15]3)[CH:10]=[CH:11][CH:12]=2)[N:7]=[C:6]([C:17]([OH:19])=[O:18])[CH:5]=1)[CH3:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 57440905Methyl 8-cyclopropyl-4-ethoxyquinoline-2-carboxylate

Produkt 1

HCID 574408968-Cyclopropyl-4-ethoxyquinoline-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21584188Chloroform methanolLösungsmittel

Versuchsvorschrift

2.0 mL of 5N NaOHaq was added to a solution of 1.10 g of methyl 4-ethoxy-8-cyclopropylquinoline-2-carboxylate in 5 mL of CHCl3/MeOH (1:1) and the mixture was stirred at room temperature for 3 hr. After the addition of 3.0 mL of 5N HCl aq, the mixture was extracted by CHCl3. The organic layer was washed by satd. brine, dried over NaSO4, then concentrated to afford 4-ethoxy-8-cyclopropylquinoline-2-carboxylic acid as a colorless solid.

Aufarbeitung

  1. extractionthe mixture was extracted by CHCl3
  2. washThe organic layer was washed by satd
  3. dry with materialbrine, dried over NaSO4
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-a18bcf50d9f3427d82b12df6f7607054
Quelldatensatz
uspto-grants-2008_08
Patentnummer
US07410976B2

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