Sodium Hydroxide → 1-Cyclopropyl-5-methoxyisoquinoline-7-carboxylic acid

HRID 2218315Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2218315
C[O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[CH:10][N:11]=[C:12]2[CH:15]2[CH2:17][CH2:16]2)=[C:7]([O:18][CH3:19])[CH:6]=1)=[O:4].[OH-].[Na+]>C1COCC1.CO>[CH:15]1([C:12]2[C:13]3[C:8](=[C:7]([O:18][CH3:19])[CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:14]=3)[CH:9]=[CH:10][N:11]=2)[CH2:16][CH2:17]1

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 57440910Methyl 1-cyclopropyl-5-methoxyisoquinoline-7-carboxylate

Produkt 1

HCID 574408921-Cyclopropyl-5-methoxyisoquinoline-7-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

1-Cyclopropyl-5-methoxy-isoquinoline-7-carboxylic acid methyl ester (4.87 g, 18.9 mmol) was dissolved in THF (50 ml) and MeOH (50 ml), and 5N NaOH aq. (18.9 ml) was added thereto. After stirred at 60° C. for 2 h, the mixture was concentrated in vacuo. The residue was triturated with H2O and 5N HCl aq. (18.9 ml) and the insoluble solid was collected through filtration to obtain the intended compound as a colorless solid.

Aufarbeitung

  1. concentrationthe mixture was concentrated in vacuo
  2. customThe residue was triturated with H2O and 5N HCl aq. (18.9 ml)
  3. filtrationthe insoluble solid was collected through filtration

Quellen und Nachweise

ORD-Eintrag
ord-922d78239cae478aafc6930a9df9cfeb
Quelldatensatz
uspto-grants-2008_08
Patentnummer
US07410976B2

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