3-Fluorophenylboronic acid → HCID 23725323, Verbindung
Reaktionsgleichung
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[F:19][C:20]1[CH:21]=[C:22](B(O)O)[CH:23]=[CH:24][CH:25]=1>>[F:18][C:15]1[CH:16]=[CH:17][C:12]([C:7]2[C:6]([C:4]3[N:3]=[CH:2][N:1]([C:24]4[CH:23]=[CH:22][CH:21]=[C:20]([F:19])[CH:25]=4)[CH:5]=3)=[C:10]([CH3:11])[O:9][N:8]=2)=[CH:13][CH:14]=1Komponenten
3
Versuchsvorschrift
As described for Example 3, 4-(1H-imidazol-4-yl)-5-methyl-3-(4-fluorophenyl)-isoxazole (73 mg, 0.3 mmol) was converted, using 3-fluorophenylboronic acid instead of 4-fluorophenylboronic acid, to the title compound (13 mg, 12%) which was obtained as an off-white solid. MS: m/e=338.3 [M+H]+.
Quellen und Nachweise
- ORD-Eintrag
- ord-3f0651676e7147e9b1a6ac66387ef85c
- Quelldatensatz
- uspto-grants-2008_08