5-Bromonicotinonitrile → HCID 11596557, Verbindung
Reaktionsgleichung
[F:1][C:2]([F:26])([F:25])[C:3]1[N:4]=[C:5]([NH:8][C:9]([C:11]2[C:16]([NH:17][C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)=[CH:15][CH:14]=[C:13]([CH3:24])[N:12]=2)=[O:10])[S:6][CH:7]=1.BrC1C=C(C#N)[CH:31]=[N:32]C=1>>[F:26][C:2]([F:1])([F:25])[C:3]1[N:4]=[C:5]([NH:8][C:9]([C:11]2[C:16]([NH:17][C:18]3[CH:19]=[N:20][CH:21]=[C:22]([C:31]#[N:32])[CH:23]=3)=[CH:15][CH:14]=[C:13]([CH3:24])[N:12]=2)=[O:10])[S:6][CH:7]=1Komponenten
3
Versuchsvorschrift
The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid (4-trifluoromethyl-thiazol-2-yl)-amide (example 18) in accordance with the general method of example 20 using 5-Bromo-3-cyanopyridine instead of 3-Bromo-4-methylpyridine to yield the final compound as an off-white solid, MS (ISP): m/e=405.4 (M+H+).
Quellen und Nachweise
- ORD-Eintrag
- ord-b80a8354eaae4fa69d86e06c37495ef3
- Quelldatensatz
- uspto-grants-2008_08
- Patentnummer