2-Amino-4-methylthiazole → 6-Methyl-3-(5-methyl-pyridin-3-ylamino)-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide

HRID 2219567

Reaktionsgleichung

Reaktionsgleichung von HRID 2219567
C(O[C:4]([C:6]1[C:11]([NH:12][C:13]2[CH:14]=[N:15][CH:16]=[C:17]([CH3:19])[CH:18]=2)=[CH:10][CH:9]=[C:8]([CH3:20])[N:7]=1)=[O:5])C.[NH2:21][C:22]1[S:23][CH:24]=[C:25]([CH3:27])[N:26]=1>>[CH3:27][C:25]1[N:26]=[C:22]([NH:21][C:4]([C:6]2[C:11]([NH:12][C:13]3[CH:14]=[N:15][CH:16]=[C:17]([CH3:19])[CH:18]=3)=[CH:10][CH:9]=[C:8]([CH3:20])[N:7]=2)=[O:5])[S:23][CH:24]=1

Komponenten

3

Edukt 2

HCID 741432-Amino-4-methylthiazoleHCID 692367736-Methyl-3-(5-methyl-pyridin-3-ylamino)-pyridine-2-carboxylic acid ethyl ester

Produkt 1

HCID 116530046-Methyl-3-(5-methyl-pyridin-3-ylamino)-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide

Versuchsvorschrift

The title compound, was prepared from 6-Methyl-3-(5-methyl-pyridin-3-ylamino)-pyridine-2-carboxylic acid ethyl ester and 2-Amino-4-methylthiazole in accordance with the general method of Example 78, step 2 to yield the final compound as a yellow solid, MS (ISP): m/e=340.3 (M+H+).

Quellen und Nachweise

ORD-Eintrag
ord-0fb805be4dde4038a9d19c4602abe65f
Quelldatensatz
uspto-grants-2008_08
Patentnummer
US07414060B2

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