Phosphate → L-Leucine

Reaktionsgleichung

N[C@H](C(NCC(NCC(N[C@H](C([NH:32][C@H:33]([C:38]([OH:40])=[O:39])[CH2:34][CH:35]([CH3:37])[CH3:36])=O)CC1C=CC=CC=1)=O)=O)=O)CC1C=CC(O)=CC=1.P([O-])([O-])([O-])=O>>[NH2:32][C@H:33]([C:38]([OH:40])=[O:39])[CH2:34][CH:35]([CH3:37])[CH3:36]

Komponenten

Edukt 2

HCID 1061Phosphate

HCID 461776Leu-Enkephalin

Produkt 1

HCID 6106L-Leucine

Versuchsvorschrift

The degradation H-Tyr-Gly-Gly-Phe-Leu-OH (SEQ ID NO: 12) (˜1.8×10−4 M) in 50 MM phosphate buffer solutions of pH 7.4 containing carboxypeptidase A (1 U/ml) was studied as described above. The pseudo first-order rate constant for the degradation was estimated to 9.8×10−1 min−1 and the corresponding half-life calculated to 0.7 min as previously described.

Aufarbeitung

wait−1 and the corresponding half-life calculated to 0.7 min

Quellen und Nachweise

ORD-Eintrag: ord-1abf1ee2c5ed4728b0063d184b1aa5eb
Quelldatensatz: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07414107B2

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