Sodium Hydroxide → sodium;(E)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate

HRID 2219827

Reaktionsgleichung

[CH3:1][CH:2]([N:4]1[C:12](/[CH:13]=[CH:14]/[C@H:15]([OH:24])[CH2:16][C@H:17]([OH:23])[CH2:18][C:19]([O:21]C)=[O:20])=[C:11]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[C:10]2[C:5]1=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH3:3].[OH-].[Na+:33]>C(#N)C>[CH3:3][CH:2]([N:4]1[C:12](/[CH:13]=[CH:14]/[CH:15]([OH:24])[CH2:16][CH:17]([OH:23])[CH2:18][C:19]([O-:21])=[O:20])=[C:11]([C:25]2[CH:26]=[CH:27][C:28]([F:31])=[CH:29][CH:30]=2)[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]1=2)[CH3:1].[Na+:33]

Komponenten

Reaktionsbedingungen

Temperatur: 60 °C

Versuchsvorschrift

Fluvastatin methyl ester (3.01 g) was dissolved in acetonitrile (60 ml) by heating and NaOH (0.28 g) was added. The mixture was stirred at about 60° C. for 1 h, cooled to room temperature, heated again to about 75° C. for 2 h, then cooled to room temperature and stirred overnight. The product was isolated by filtration under nitrogen, washed with acetonitrile (40 ml) and dried at 50° C. in a vacuum oven for 24 h to obtain 1.07 g (34.9%) of fluvastatin sodium crystal Form I.

Aufarbeitung

temperatureby heating
temperaturecooled to room temperature
temperatureheated again to about 75° C. for 2 h
temperaturecooled to room temperature
stirringstirred overnight
customThe product was isolated by filtration under nitrogen
washwashed with acetonitrile (40 ml)
customdried at 50° C. in a vacuum oven for 24 h

Quellen und Nachweise

ORD-Eintrag: ord-8b7976a5df984b54bbc8ebf245a80dc2
Quelldatensatz: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07414140B2

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