Diisobutylaluminumhydride → Benzo[b]thiophene, 7-fluoro-4-methoxy-

Temperatur

35 °C

To a solution of 7-fluoro-4-methoxy-1-benzothiophen-2(3H)-one (1.06, 5.4 mmol) in dichloromethane (10 mL) at 0° C. was added slowly a solution of diisobutylaluminium hydride in dichloromethane (1 M, 8.04 mL, 8.0 mmol). After 30 mins the reaction was quenched by careful addition of aqueous hydrochloric acid (6 N, 25 mL). The mixture was concentrated to remove the dichloromethane, the aqueous residue was then stirred at 35° C. for 2 h. The aqueous solution was extracted with diethyl ether (3×50 mL), washed with aqueous sodium hydroxide (2 N, 50 mL), brine (50 mL) then dried (MgSO4) and the solvent evaporated in vacuo to give the title compound (0.86 g, 87%) as a purple oil; δH 7.44-7.38 (1H, m, ArH), 7.36-7.24 (1H, m, ArH), 6.88-6.80 (1H, m, ArH), 6.57-6.49 (1H, m, ArH) and 3.82 (3H, s, OCH3).

1. customAfter 30 mins the reaction was quenched by careful addition of aqueous hydrochloric acid (6 N, 25 mL)
2. concentrationThe mixture was concentrated
3. customto remove the dichloromethane
4. extractionThe aqueous solution was extracted with diethyl ether (3×50 mL)
5. washwashed with aqueous sodium hydroxide (2 N, 50 mL), brine (50 mL)
6. dry with materialthen dried (MgSO4)
7. customthe solvent evaporated in vacuo

ORD-Eintrag

ord-7bf3b3cd5781498a9af258dfc5d68e90

Quelldatensatz

uspto-grants-2008_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07417064B2