Hydrochloric Acid → 4'-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-amino]ethoxy]-3-(isopropylthio)-4-biphenylcarboxylic acid hydrochloride

HRID 2220437Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2220437
[OH:1][C@H:2]([C:29]1[CH:34]=[CH:33][C:32]([OH:35])=[CH:31][CH:30]=1)[C@@H:3]([NH:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([O:23]C)=[O:22])=[C:17]([S:25][CH:26]([CH3:28])[CH3:27])[CH:16]=2)=[CH:11][CH:10]=1)[CH3:4].[OH-].[Na+].[ClH:38]>CO>[ClH:38].[OH:1][C@H:2]([C:29]1[CH:34]=[CH:33][C:32]([OH:35])=[CH:31][CH:30]=1)[C@@H:3]([NH:5][CH2:6][CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([OH:23])=[O:22])=[C:17]([S:25][CH:26]([CH3:28])[CH3:27])[CH:16]=2)=[CH:13][CH:14]=1)[CH3:4]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69103361methyl 4'-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-amino]ethoxy]-3-(isopropylthio)-4-biphenylcarboxylate

Produkt 1

HCID 691028394'-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-amino]ethoxy]-3-(isopropylthio)-4-biphenylcarboxylic acid hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of methyl 4′-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethoxy]-3-(isopropylthio)-4-biphenylcarboxylate (110 mg) in methanol (1.65 ml) was added sodium hydroxide aqueous solution (1N 1.11 ml) and stirred at room temperature overnight. To the mixture was added hydrochloric acid aqueous solution (1N, 1.22 ml) and concentrated in vacuo. The residue was solved with methanol, added hydrogen chloride 1,4-dioxane solution (4M), concentrated in vacuo and dried to give 4′-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-amino]ethoxy]-3-(isopropylthio)-4-biphenylcarboxylic acid hydrochloride (97 mg).

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. additionadded hydrogen chloride 1,4-dioxane solution (4M)
  3. concentrationconcentrated in vacuo
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-706566f822f54639b63be178769e5a2d
Quelldatensatz
uspto-grants-2008_08
Patentnummer
US07417060B2

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