2-Oxo-[1,4']bipiperidinyl-1'-carboxylic acid benzyl ester → [1,4'-Bipiperidin]-2-one

HRID 2221081Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2221081
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([N:17]2[CH2:22][CH2:21][CH2:20][CH2:19][C:18]2=[O:23])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>[OH-].[OH-].[Pd+2].C(O)C>[N:17]1([CH:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)[CH2:22][CH2:21][CH2:20][CH2:19][C:18]1=[O:23]

Komponenten

4

Edukt 1

HCID 233699802-Oxo-[1,4']bipiperidinyl-1'-carboxylic acid benzyl ester

Produkt 1

HCID 21839852[1,4'-Bipiperidin]-2-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

2-Oxo-[1,4′]bipiperidinyl-1′-carboxylic acid benzyl ester (2.5 g) and Pearlman's catalyst (0.50 g) was stirred in ethanol (30 mL) under hydrogen (1 atm). After 20 hours the reaction as filtered through celite and concentrated. The title compound was obtained as a white solid (1.45 g). MS: m/z=183 (M+H).

Aufarbeitung

  1. customAfter 20 hours the reaction
  2. filtrationas filtered through celite and
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-cad510d22ef144e9bbc92fbeab35ec16
Quelldatensatz
uspto-grants-2008_05
Patentnummer
US07368461B2

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