2-Pyrrolidone → HCID 69215404, Verbindung

HRID 2221366Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2221366
Cl[CH2:2][Si:3]([O:6][CH3:7])([CH3:5])[CH3:4].[O-:8][C:9]#[N:10].[K+].[NH:12]1[CH2:16][CH2:15][CH2:14][C:13]1=[O:17]>CN(C=O)C>[CH3:7][O:6][Si:3]([CH2:2][NH:10][C:9]([N:12]1[CH2:16][CH2:15][CH2:14][C:13]1=[O:17])=[O:8])([CH3:5])[CH3:4]

Komponenten

5

Edukt 3

HCID 120252-PyrrolidoneHCID 560623(Chloromethyl)methoxydimethylsilaneHCID 11378442Potassium cyanate

Produkt 1

HCID 69215404HCID 69215404, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

A mixture of 69.3 g of (chloromethyl)methoxydimethyl-silane, 40.6 g of potassium cyanate and 42.6 g of 2-pyrrolidinone in 150 ml of anhydrous DMF was heated at 130° C. with stirring for 5 h. The solvent was then removed under reduced pressure. This gave N-[(methoxydimethylsilyl)methyl]-2-oxo-1-pyrrolidinecarboxamide in quantitative yield with a purity of >90% (analysis by 1H NMR, see Example 2a).

Aufarbeitung

  1. customThe solvent was then removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-40873512c0c041d4b579c07ef7f793aa
Quelldatensatz
uspto-grants-2008_05
Patentnummer
US07368586B2

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