1,1-Bis(methylthio)-2-nitroethylene → 1-(2-Chloro-5-pyridylmethyl)4-methyl-2-(nitromethylene)imidazolidine

HRID 22215

Reaktionsgleichung

Reaktionsgleichung von HRID 22215
[NH2:1][CH:2]([CH3:13])[CH2:3][NH:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([Cl:12])=[N:10][CH:11]=1.[N+:14]([CH:17]=[C:18](SC)SC)([O-:16])=[O:15]>CO>[Cl:12][C:9]1[CH:8]=[CH:7][C:6]([CH2:5][N:4]2[CH2:3][CH:2]([CH3:13])[NH:1][C:18]2=[CH:17][N+:14]([O-:16])=[O:15])=[CH:11][N:10]=1

Komponenten

4

Edukt 2

HCID 836231,1-Bis(methylthio)-2-nitroethyleneHCID 139209182-Amino-1-(2-chloro-5-pyridylmethylamino)propane

Produkt 1

HCID 867421431-(2-Chloro-5-pyridylmethyl)4-methyl-2-(nitromethylene)imidazolidineAusbeute 73 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 2 g of 2-amino-1-(2-chloro-5-pyridylmethylamino)propane, 1.6 g of 1-nitro-2,2-bis(methylthio)ethylene and 20 ml of methanol was refluxed for hours with stirring. A crystaline product was precipitated after standing at room temperature. The product was filtered with suction, washed with methanol and then dried in vacuum. 1.9 g of 1-(2-chloro-5-pyridylmethyl)-4-methyl-2-(nitromethylene)imidazolidine was obtained in form of light yellow crystals.

Aufarbeitung

  1. temperaturewas refluxed for hours
  2. customA crystaline product was precipitated
  3. customafter standing at room temperature
  4. filtrationThe product was filtered with suction
  5. washwashed with methanol
  6. customdried in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-1bd1791614cd400c8e7f793356fce6e3
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05428032

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