Hydrochloric Acid → HCID 178437609, Verbindung

HRID 2221706Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2221706
[CH2:1]([C:3]1[S:4][C:5]([CH3:25])=[C:6](/[CH:8]=[CH:9]/[C:10]2[C:11]([O:21]COC)=[N:12][N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:14]=2)[N:7]=1)[CH3:2].[ClH:26]>CO>[ClH:26].[CH2:1]([C:3]1[S:4][C:5]([CH3:25])=[C:6](/[CH:8]=[CH:9]/[C:10]2[C:11]([OH:21])=[N:12][N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:14]=2)[N:7]=1)[CH3:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 230764842-ethyl-4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-5-methyl-1,3-thiazole

Produkt 1

HCID 178437609HCID 178437609, VerbindungAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To a solution of 2-ethyl-4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-5-methyl-1,3-thiazole (3.21 g) in methanol (75 mL) was added concentrated hydrochloric acid (1.5 mL) at room temperature, and the mixture was stirred at 50° C. for 2 hrs. The reaction mixture was evaporated under reduced pressure, and the residue was washed with ethyl acetate-methanol to give 4-[(E)-2-(2-ethyl-5-methyl-1,3-thiazol-4-yl)ethenyl]-1-phenyl-1H-pyrazol-3-ol.hydrochloride (3.02 g, yield 96%) as pale-yellow prism crystals. melting point: 184-186° C.

Aufarbeitung

  1. customThe reaction mixture was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate-methanol

Quellen und Nachweise

ORD-Eintrag
ord-07df3f0eb2f94eadb28fb651e4cba632
Quelldatensatz
uspto-grants-2008_05
Patentnummer
US07368578B2

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