Hydrazine → HCID 17990173, Verbindung

HRID 2222229

Reaktionsgleichung

Reaktionsgleichung von HRID 2222229
Cl[C:2]1[N:7]([CH2:8][CH:9]2[CH2:11][CH2:10]2)[C:6](=[O:12])[NH:5][C:4](=[O:13])[CH:3]=1.[NH2:14][NH2:15]>C(O)C>[CH:9]1([CH2:8][N:7]2[C:2]([NH:14][NH2:15])=[CH:3][C:4](=[O:13])[NH:5][C:6]2=[O:12])[CH2:11][CH2:10]1

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 179901746-Chloro-1-cyclopropylmethyluracil

Produkt 1

HCID 17990173HCID 17990173, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
82.5 °C

Versuchsvorschrift

6-Chloro-1-cyclopropylmethyluracil (24.34 g, 0.12 mol) was suspended in absolute ethanol (245 mL) under nitrogen. Anhydrous hydrazine (11.69 g, 0.36 mol) was added via syringe in excess, resulting in a clear-yellow solution. The reaction mixture was heated at 80-85° C. for one hour; bright yellow crystals began forming within minutes of the application of heat. The reaction mixture was cooled to room temperature and then in an ice bath, and the crude product collected by filtration. N2H4×HCl was removed by triturating with cold water to give the product as a pale yellow solid, 20.47 g (86%). Mp 221° C. (dec).

Aufarbeitung

  1. customresulting in a clear-yellow solution
  2. custombright yellow crystals began forming within minutes of the application
  3. temperatureof heat
  4. temperatureThe reaction mixture was cooled to room temperature
  5. filtrationin an ice bath, and the crude product collected by filtration
  6. customN2H4×HCl was removed
  7. customby triturating with cold water

Quellen und Nachweise

ORD-Eintrag
ord-5eb0f140a6fa4afd9002c08e665fec3b
Quelldatensatz
uspto-grants-2008_05
Patentnummer
US07371757B2

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