Trifluoroacetic acid → HCID 69282442, Verbindung

Beteiligte Stoffe

Reaktionsschritte

[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester (2.90 g, 6.91 mmol) was dissolved in CH2Cl2 (10 ml). Trifluoroacetic acid (10 ml) was added and the mixture was stirred for 90 minutes at r.t. until analytical HPLC indicated complete consumption of the starting material. The solvent was evaporated, the residue was taken up in ethyl acetate, washed (water), and dried (Na2SO4). After evaporation of the solvent, the title compound, MS: m/e=320.4 (M+H+), (1.73 g, 69%) was obtained by chromatographic purification of the residue (silica gel, MeOH, CH2Cl2).

Herkunft & Nachweise