Trifluoroacetic acid → HCID 59715655, Verbindung

HRID 2223468Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2223468
FC(F)(F)C(O)=O.[CH2:8]([C:12]1[CH:28]=[CH:27][C:15]([CH2:16][C:17]2[C:22]([O:23]COC)=[CH:21][CH:20]=[CH:19][N:18]=2)=[CH:14][CH:13]=1)[CH2:9][CH2:10][CH3:11].C(=O)([O-])O.[Na+].C(OCC)(=O)C>C(Cl)Cl>[CH2:8]([C:12]1[CH:28]=[CH:27][C:15]([CH2:16][C:17]2[C:22]([OH:23])=[CH:21][CH:20]=[CH:19][N:18]=2)=[CH:14][CH:13]=1)[CH2:9][CH2:10][CH3:11]

Komponenten

6

Edukt 4

HCID 6422Trifluoroacetic acidHCID 8857Ethyl AcetateHCID 516892Sodium BicarbonateHCID 57712181HCID 57712181, Verbindung

Produkt 1

HCID 59715655HCID 59715655, VerbindungAusbeute 88,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Trifluoroacetic acid (1 ml) was added to a solution of the compound of Example B229 (256 mg, 0.849 mmol) in methylene chloride (5 ml), and this reaction mixture was stirred at room temperature overnight. After a saturated aqueous sodium hydrogencarbonate solution and ethyl acetate were added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (182 mg).

Aufarbeitung

  1. washthe reaction mixture was washed with saturated brine
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-1be49c2b185743b1ba968f745987973f
Quelldatensatz
uspto-grants-2008_05
Patentnummer
US07375204B2

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