Trifluoroacetic acid → 2-(4-Benzylpiperidin-1-yl)ethan-1-amine

HRID 2223711

Reaktionsgleichung

Reaktionsgleichung von HRID 2223711
C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][CH:13]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:12][CH2:11]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)(Cl)Cl>[CH2:16]([CH:13]1[CH2:12][CH2:11][N:10]([CH2:9][CH2:8][NH2:7])[CH2:15][CH2:14]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 59715914[2-(4-Benzyl-piperidin-1-yl)-ethyl]-carbamic acid tert-butyl ester

Produkt 1

HCID 27798312-(4-Benzylpiperidin-1-yl)ethan-1-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

[2-(4-Benzyl-piperidin-1-yl)-ethyl]-carbamic acid tert-butyl ester (1.34 g, 4.2 mmol) is dissolved in CHCl3 (3 mL) and treated with TFA (3 mL) for 2 h at 20° C. The solvent is evaporated, the residue dissolved CH2Cl2 (100 mL) and washed with 1M aqueous NaOH (2×30 mL). The organic layer is dried (Na2SO4), filtered and concentrated to provide the title compound.

Aufarbeitung

  1. customThe solvent is evaporated
  2. dissolutionthe residue dissolved CH2Cl2 (100 mL)
  3. washwashed with 1M aqueous NaOH (2×30 mL)
  4. dry with materialThe organic layer is dried (Na2SO4)
  5. filtrationfiltered
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-613c097532794b6eb35e701bbccad6b1
Quelldatensatz
uspto-grants-2008_05
Patentnummer
US07375227B2

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