1,3-Bis-(2-methyl-quinolin-4-yl)urea → 4-Benzyl-1-{2-[3-(2-methyl-quinolin-4-yl)-ureido]-ethyl}-piperidine-4-carboxylic acid

HRID 2223738Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2223738
Cl.Cl.[NH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][C:9]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)([C:12]([OH:14])=[O:13])[CH2:8][CH2:7]1.[CH3:22][C:23]1[CH:32]=[C:31]([NH:33][C:34](NC2C3C(=CC=CC=3)N=C(C)C=2)=[O:35])[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[N:24]=1>C1COCC1>[CH2:15]([C:9]1([C:12]([OH:14])=[O:13])[CH2:10][CH2:11][N:6]([CH2:5][CH2:4][NH:3][C:34]([NH:33][C:31]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[N:24]=[C:23]([CH3:22])[CH:32]=2)=[O:35])[CH2:7][CH2:8]1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Komponenten

4

Edukt 2

HCID 179565591,3-Bis-(2-methyl-quinolin-4-yl)ureaHCID 692175151-(2-Amino-ethyl)-4-benzyl-piperidine-4-carboxylic acid dihydrochloride

Produkt 1

HCID 179564534-Benzyl-1-{2-[3-(2-methyl-quinolin-4-yl)-ureido]-ethyl}-piperidine-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

1-(2-Amino-ethyl)-4-benzyl-piperidine-4-carboxylic acid dihydrochloride (3.35 g, 10 mmol), 1,3-bis-(2-methyl-quinolin-4-yl)-urea (3.43 g, 10 mmol) and TEA (5 mL, 36 mmol) are suspended in THF (50 mL) and heated at reflux for 48 h. The solvent is evaporated and the residue purified by HPLC to provide the title compound.

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux for 48 h
  3. customThe solvent is evaporated
  4. customthe residue purified by HPLC

Quellen und Nachweise

ORD-Eintrag
ord-f403d4cbf08949c49d7a3a02604b60f7
Quelldatensatz
uspto-grants-2008_05
Patentnummer
US07375227B2

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