3-(Bromomethyl)-2,6-dichloropyridine → 6-Acetyl-2,8-dichloro-5,6-dihydropyrido[3,2-c][1]benzazocine
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:12]=[CH2:13])=[C:6]([NH:8][C:9](=[O:11])[CH3:10])[CH:7]=1.Br[CH2:15][C:16]1[C:17](Cl)=[N:18][C:19]([Cl:22])=[CH:20][CH:21]=1.C(N1C2C=CC=CC=2C=CC2N=C(Cl)C(F)=CC=2C1)(=O)C>>[C:9]([N:8]1[C:6]2[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[CH:12]=[CH:13][C:17]2[N:18]=[C:19]([Cl:22])[CH:20]=[CH:21][C:16]=2[CH2:15]1)(=[O:11])[CH3:10]Komponenten
4
Versuchsvorschrift
The title compound was prepared from 6C and 13B by a route analogous to that used for the preparation of 1D. HPLC Rt=2.769 min; LCMS Found: (M+H)+=319.