Sodium Hydroxide → 4'-Methyl-biphenyl-3-carboxylic acid

HRID 22247

Reaktionsgleichung

Reaktionsgleichung von HRID 22247
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([O:16]CC)=[O:15])[CH:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([OH:16])=[O:15])[CH:9]=2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 107287544'-Methyl-biphenyl-3-carboxylic acid ethyl ester

Produkt 1

HCID 27739784'-Methyl-biphenyl-3-carboxylic acidAusbeute 67,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of ethyl 4'-methylbiphenyl-3-carboxylate (4.0 g) in ethanol (50 ml) was added a solution of 10 ml of 10% aqueous sodium hydroxide, and the mixture refluxed for 2 hours. Solvent was removed under reduced pressure, water added to the residue, and the solution filtered. The filtrate was acidified with dilute hydrochloric acid, and the white solid filtered off and dried under vacuum, yielding 2.4 g of 4'-methylbiphenyl-3-carboxylic acid m.p. 192° C.

Aufarbeitung

  1. temperaturethe mixture refluxed for 2 hours
  2. customSolvent was removed under reduced pressure, water
  3. additionadded to the residue
  4. filtrationthe solution filtered
  5. filtrationthe white solid filtered off
  6. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-db788f0e684c4545913753d0f555e1f7
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05428037

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