Sodium Hydroxide → HCID 19004073, Verbindung

HRID 2225371Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2225371
[OH-].[Na+].[CH:3]1[C:13]2[CH2:12][C:11]3[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=3[C:9]([N:18]3[CH2:23][CH2:22][N:21]([CH2:24][C:25]([O:27]CC)=[O:26])[CH2:20][CH2:19]3)=[N:8][C:7]=2[CH:6]=[CH:5][CH:4]=1>CO>[CH:3]1[C:13]2[CH2:12][C:11]3[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=3[C:9]([N:18]3[CH2:19][CH2:20][N:21]([CH2:24][C:25]([OH:27])=[O:26])[CH2:22][CH2:23]3)=[N:8][C:7]=2[CH:6]=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 19004087HCID 19004087, Verbindung

Produkt 1

HCID 19004073HCID 19004073, VerbindungAusbeute 63,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

2N Aqueous sodium hydroxide solution (5 ml) was added to a solution of 1.82 g of ethyl 4-(11H-dibenz[b,e]azepin-6-yl)-1-piperazineacetate in 18 ml of methanol. The solution was refluxed for 30 min and then concentrated. The residue was dissolved in hot water and the solution was neutralized with 0.5N hydrochloric acid. The precipitates were collected by filtration to give 1.06 g of colorless crystals, which were recrystallized from ethanol to give colorless granules, mp 181°-183° C. (decomp.).

Aufarbeitung

  1. temperatureThe solution was refluxed for 30 min
  2. concentrationconcentrated
  3. dissolutionThe residue was dissolved in hot water
  4. filtrationThe precipitates were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-b6a08c05d4ed4dcca12e13a5b65b608c
Quelldatensatz
uspto-grants-1994_09
Patentnummer
US05344828

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