HCID 178418361, Verbindung → HCID 178490507, Verbindung

HRID 2225521

Reaktionsgleichung

Reaktionsgleichung von HRID 2225521
[CH3:1][N:2]([CH3:28])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]([C@H:21]1[CH2:26][CH2:25][C@H:24]([CH3:27])[CH2:23][CH2:22]1)[C:8](=[O:20])[CH:9]=[CH:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([O:18][CH3:19])[CH:12]=1.[H][H]>CO.[C].[Pd]>[CH3:28][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]([C@H:21]1[CH2:26][CH2:25][C@H:24]([CH3:27])[CH2:23][CH2:22]1)[C:8](=[O:20])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([O:18][CH3:19])[CH:12]=1

Komponenten

5

Edukt 2

HCID 178418361HCID 178418361, VerbindungHCID 178490506HCID 178490506, Verbindung

Produkt 1

HCID 178490507HCID 178490507, VerbindungAusbeute 91,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

0.05 g of 10% palladium-carbon was added to a solution of 1 g of N-(4-dimethylaminobutyl)-N-(trans-4-methylcyclohexyl)-4-hydroxy-3-methoxycinnamamide (Example 75) in 60 ml of methanol. Under normal-pressure hydrogen gas, the solution was reacted for 16 hours, while it was vigorously stirred. After reaction, the catalyst was filtered out, and the solvent was removed in vacuo from the filtrate, yielding 0.92 g of N-(4-dimethylaminobutyl)-N-(trans-4-methylcyclohexyl)-3-(4-hydroxy-3-methoxyphenyl)propionamide (a compound of the present invention) as a pale yellow oily oil, which had the following physiochemical properties:

Aufarbeitung

  1. customAfter reaction
  2. filtrationthe catalyst was filtered out
  3. customthe solvent was removed in vacuo from the filtrate

Quellen und Nachweise

ORD-Eintrag
ord-7fad1ad9d1ee4eabac525e294b0ab22a
Quelldatensatz
uspto-grants-1994_09
Patentnummer
US05344845

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