4-[[2-(Cyclohexyloxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester → 4-[[2-(Cyclohexyloxy)ethyl]oxy]-alphaoxobenzeneacetic acid

HRID 2225700Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2225700
C[O:2][C:3](=[O:22])[C:4](=[O:21])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][O:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[CH:15]1([O:14][CH2:13][CH2:12][O:11][C:8]2[CH:7]=[CH:6][C:5]([C:4](=[O:21])[C:3]([OH:22])=[O:2])=[CH:10][CH:9]=2)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1

Komponenten

4

Edukt 1

HCID 543210414-[[2-(Cyclohexyloxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester

Produkt 1

HCID 190043524-[[2-(Cyclohexyloxy)ethyl]oxy]-alphaoxobenzeneacetic acidAusbeute 89,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

A mixture of 4-[[2-(cyclohexyloxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.7 g) in methanol (10 mL) and 0.5N sodium hydroxide (7 mL) was treated as in Example 19. Extraction with diethyl ether provided material which was crystallized from diethyl ether-hexane to give 0.6 g of colorless 4-[[2-(cyclohexyloxy)ethyl]oxy]-alphaoxobenzeneacetic acid, mp 96°-98° C.

Aufarbeitung

  1. additionwas treated as in Example 19
  2. extractionExtraction with diethyl ether provided material which
  3. customwas crystallized from diethyl ether-hexane

Quellen und Nachweise

ORD-Eintrag
ord-90b957c3af2c469c9d3603aee62c589e
Quelldatensatz
uspto-grants-1994_09
Patentnummer
US05344843

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