Potassium Hydroxide → HCID 54288038, Verbindung

HRID 2226118Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2226118
[CH3:1][C:2]1([CH3:20])[CH2:11][C:10]([CH3:13])([CH3:12])[C:9]2[C:4](=[CH:5][C:6]([C:14]#[C:15][Si](C)(C)C)=[CH:7][CH:8]=2)[O:3]1.[OH-].[K+]>C(O)(C)C>[CH3:1][C:2]1([CH3:20])[CH2:11][C:10]([CH3:12])([CH3:13])[C:9]2[C:4](=[CH:5][C:6]([C:14]#[CH:15])=[CH:7][CH:8]=2)[O:3]1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 189663522,2,4,4-Tetramethyl-7-trimethylsilylethynyl-chroman2×

Produkt 1

HCID 54288038HCID 54288038, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

To a solution of 1.16 g (4.1 mmol) of 2,2,4,4-tetramethyl-7-trimethylsilylethynyl-chroman (Compound 43) in 3 ml of isopropanol was added 5 ml of ethanolic KOH solution. The reaction mixture was stirred at room temperature for 24 hours and the alcohol was then removed under vacuum. The residue was extracted with 2×10 ml of ether and the combined ether extracts were washed with 15 ml of water and 20 ml of saturated NaCl solution and then dried (MgSO4). The solvent was removed in vacuo and the residue purified by Kugelrohr distillation to give the title compound as a white crystalline solid.

Aufarbeitung

  1. customthe alcohol was then removed under vacuum
  2. extractionThe residue was extracted with 2×10 ml of ether
  3. washthe combined ether extracts were washed with 15 ml of water and 20 ml of saturated NaCl solution
  4. dry with materialdried (MgSO4)
  5. customThe solvent was removed in vacuo
  6. distillationthe residue purified by Kugelrohr distillation

Quellen und Nachweise

ORD-Eintrag
ord-db628e0ff683482298be3287c72d1e65
Quelldatensatz
uspto-grants-1994_09
Patentnummer
US05346895

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