Oxalic Acid → (+)-3-[4-[N-n-Propyl-N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]Decane (Oxalate)

HRID 2226188Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2226188
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH:6]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[C:22](=[O:23])[C:21]3([CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)[CH2:20][C:19]1=[O:29])[CH2:7][O:8]2.[C:30]([OH:35])(=[O:34])[C:31]([OH:33])=[O:32].CO[C:38]1[CH:47]=CC=C2[C:39]=1CC(NCCCCN1C(=O)C3(CCCCC3)CC1=O)CO2.C(O)(=O)C(O)=O>>[C:30]([OH:35])(=[O:34])[C:31]([OH:33])=[O:32].[CH2:39]([N:13]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[C:22](=[O:23])[C:21]2([CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)[CH2:20][C:19]1=[O:29])[CH:6]1[CH2:5][C:4]2[C:9](=[CH:10][CH:11]=[CH:12][C:3]=2[O:2][CH3:1])[O:8][CH2:7]1)[CH2:38][CH3:47]

Komponenten

4

Edukt 3

HCID 971Oxalic AcidHCID 18966575(+)-3-[4-[N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]DecaneHCID 18966585(+)-3-{4-[N-(5-Methoxy-3-Chromanyl)Amino]Butyl}-2,4-Dioxo-3-Azaspiro[4.5]Decane Oxalate

Produkt 1

HCID 18966570(+)-3-[4-[N-n-Propyl-N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]Decane (Oxalate)

Versuchsvorschrift

Using the procedure described in Example 10, but replacing the compound of Example 9 by the compound of Example 28, the product of the title is obtained. It is salified with oxalic acid.

Aufarbeitung

  1. customthe product of the title is obtained

Quellen und Nachweise

ORD-Eintrag
ord-99008ff41d974c53810c472edd229380
Quelldatensatz
uspto-grants-1994_09
Patentnummer
US05346916

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