Dimethylformamide dimethyl acetal → 1-(3-trifluoromethylbenzoyl)-1-methanesulfonyl-2-(N,N-dimethylamino)ethene

HRID 2226704Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2226704
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([C:9](=[O:15])[CH2:10][S:11]([CH3:14])(=[O:13])=[O:12])[CH:6]=[CH:7][CH:8]=1.CO[CH:20](OC)[N:21]([CH3:23])[CH3:22]>C1(C)C=CC=CC=1>[F:17][C:2]([F:1])([F:16])[C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][CH:8]=1)[C:9]([C:10]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:20][N:21]([CH3:23])[CH3:22])=[O:15]

Komponenten

4

Edukt 2

HCID 78373Dimethylformamide dimethyl acetalHCID 27755062-(Methylsulfonyl)-1-(3-(trifluoromethyl)phenyl)ethanone

Produkt 1

HCID 541640061-(3-trifluoromethylbenzoyl)-1-methanesulfonyl-2-(N,N-dimethylamino)etheneAusbeute 99,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

2.5 g of m-trifluoromethyl-α-methanesulfonylacetophenone and 1.4 g of N,N-dimethylformamide dimethylacetal were dissolved in 40 ml of toluene, and the resulting mixture was heated under reflux for 2 hours. The solvent was distilled away under reduced pressure. The residue was treated with column chromatography on silica gel, thereby obtaining 3 g of 1-(3-trifluoromethylbenzoyl)-l-methanesulfonyl-2-(N,N-dimethylamino)ethene (Compound 205).

Aufarbeitung

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 2 hours
  3. distillationThe solvent was distilled away under reduced pressure
  4. additionThe residue was treated with column chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-16f91b131a9540208f478a2cd7fa2a70
Quelldatensatz
uspto-grants-1994_09
Patentnummer
US05349108

Notizen zur Reaktion

Wird geladen…