Lithium amide → 3-Dimethylamino-5-(methylthio)benzo[b]thiophene-2-carboxamide
Reaktionsgleichung
[CH3:1][N:2]([CH3:18])[C:3]1[C:4]2[CH:15]=[C:14]([S:16][CH3:17])[CH:13]=[CH:12][C:5]=2[S:6][C:7]=1[C:8](OC)=[O:9].[NH2-:19].[Li+]>>[CH3:1][N:2]([CH3:18])[C:3]1[C:4]2[CH:15]=[C:14]([S:16][CH3:17])[CH:13]=[CH:12][C:5]=2[S:6][C:7]=1[C:8]([NH2:19])=[O:9]Komponenten
3
Versuchsvorschrift
Prepared from methyl 3-dimethylamino-5-(methylthio)benzo[b]thiophene-2-carboxylate by reaction with lithium amide as described in Example 19. Purification of the crude product by flash chromatography (silica gel, elution with 30% ethyl acetate in hexane) gives 64% of product; mp=140°-142° C.
Aufarbeitung
- customPurification of the crude product
- washby flash chromatography (silica gel, elution with 30% ethyl acetate in hexane)
Quellen und Nachweise
- ORD-Eintrag
- ord-7857070c950747879c9bcfc79a032e5e
- Quelldatensatz
- uspto-grants-1994_09
- Patentnummer
- US05350748
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