Triphenylphosphine → [3-(4-[2-Tetrahydropyranyloxy]phenyl)propyl]triphenylphosphonium bromide

HRID 2227107Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2227107
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][Br:17])=[CH:10][CH:9]=1.[C:18]1([P:24]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CN(C)C=O>[Br-:17].[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][P+:24]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)=[CH:10][CH:9]=1

Komponenten

4

Edukt 2

HCID 11776TriphenylphosphineHCID 184717901-(4'-(2-Tetrahydropyranyloxy)phenyl)-3-bromopropane

Produkt 1

HCID 18471791[3-(4-[2-Tetrahydropyranyloxy]phenyl)propyl]triphenylphosphonium bromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a solution of 1-(4′-(2-tetrahydropyranyloxy)phenyl)-3-bromopropane 3C (4.2 g) in anhydrous dimethylformamide (11.3 mL) is added triphenylphosphine (6.12 g). The reaction mixture is stirred under nitrogen at 100° C. overnight. The reaction mixture is then cooled to room temperature. The white precipitate is filtered and washed with ethyl acetate, then dried under vacuum.

Aufarbeitung

  1. temperatureThe reaction mixture is then cooled to room temperature
  2. filtrationThe white precipitate is filtered
  3. washwashed with ethyl acetate
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-b72bb3d0d75f46bfb1032efeb930efd4
Quelldatensatz
uspto-grants-2002_07
Patentnummer
US06413448B1

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