HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Formaldehyde → 5-Methoxy-2-methylindan-1-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Formaldehyde | HCID 712 | — |
| Edukt | Hexane | HCID 8058 | — |
| Edukt | Potassium Hydroxide | HCID 14797 | — |
| Edukt | 5-Methoxyindan-1-one | HCID 78787 | — |
| Katalysator | Pentacarbonyliron(0) | HCID 518773 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | 5-Methoxy-2-methylindan-1-one | HCID 12290490 | 44% |
Reaktionsschritte
5-Methoxy indanone was treated with aqueous formaldehyde in the presence of iron pentacarbonyl and KOH in ethanol according to G. Cainelli et. al., Tetrahedron Letters 27, 2491 (1973). After chromatography (hexane:ethylacetate=7:3) over SiO2, a 44% yield of white crystals was obtained (m.p. 73-76° C.).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06416746B1 |
| Quelldatensatz | uspto-grants-2002_07 |
| ORD ID | ord-25fd0c8a62c34b399dc7840abb978e0e |
| Quellennotiz | uspto-grants-2002_07 |